Dronedarone → 2-Butylbenzofuran-5-amine

HRID 541093

반응식

HRID 541093 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[O:13][C:12]2[CH:11]=[CH:10][C:9]([NH:14]S(C)(=O)=O)=[CH:8][C:7]=2[C:6]=1C(C1C=CC(OCCCN(CCCC)CCCC)=CC=1)=O.C(C1OC2C=CC([N+]([O-])=O)=CC=2C=1)CCC.[H][H]>[Pt]=O>[CH2:4]([C:5]1[O:13][C:12]2[CH:11]=[CH:10][C:9]([NH2:14])=[CH:8][C:7]=2[CH:6]=1)[CH2:3][CH2:2][CH3:1]

참가 물질

5

반응물 3

HCID 208898DronedaroneHCID 98373582-Butyl-5-nitrobenzofuranHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 98133112-Butylbenzofuran-5-amine

시약·촉매·용매 1

HCID 82844Platinum oxide (PtO)촉매

실험 절차

Patent application WO0248132 describes a method for the synthesis of dronedarone using 2-n-butyl-5-nitro-benzofuran which is reduced, under pressure, with hydrogen in the presence of platinum oxide as catalyst in order to form 2-n-butyl-5-amino-benzofuran. This benzofuran derivative is then subjected to the action of methanesulfonyl chloride, which gives 2-n-butyl-5-methanesulfonamido-benzofuran which is treated with 4-[3-(di-n-butylamino)-propoxy]-benzoyl chloride to give dronedarone.

출처 및 근거

ORD 기록
ord-bdb64b5d11dc4e94acf70f3002e9ca41
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871956B2

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