1,4-Dioxane hydrochloride → N,N-dimethylazetidine-3-carboxamide hydrochloride

HRID 541146노트

반응식

HRID 541146 반응식
[CH3:1][N:2]([CH3:16])[C:3]([CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:17].O1CCOCC1>>[ClH:17].[CH3:1][N:2]([CH3:16])[C:3]([CH:5]1[CH2:8][NH:7][CH2:6]1)=[O:4]

참가 물질

3

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59492610Tert-butyl 3-(dimethylcarbamoyl)azetidine-1-carboxylate

생성물 1

HCID 53308702N,N-dimethylazetidine-3-carboxamide hydrochloride

실험 절차

A mixture of t-butyl 3-dimethylcarbamoyl-azetidine-1-carboxylate (0.365 g) and 4N hydrogen chloride/dioxane solution (5 ml) was stirred at room temperature for 5 hr 15 min. The reaction mixture was concentrated under reduced pressure, dioxane was added to the obtained residue and the mixture was concentrated again under reduced pressure. The obtained residue was dried under reduced pressure at 60° C. to give the title compound (0.290 g). The obtained residue was directly used for the next reaction without further purification.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure, dioxane
  2. additionwas added to the obtained residue
  3. concentrationthe mixture was concentrated again under reduced pressure
  4. customThe obtained residue was dried under reduced pressure at 60° C.

출처 및 근거

ORD 기록
ord-52b9db1feb0043069cb2fa16751bae18
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871934B2

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