Einecs 211-027-4 → 3-Hydroxy-indeno[1,2-b]pyridin-5-one

HRID 541151노트

반응식

HRID 541151 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:6]2=[N:7][CH:8]=1.[Cl-].[NH+]1C=CC=CC=1>N1C=CC=CC=1>[OH:2][C:3]1[CH:4]=[C:5]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:6]2=[N:7][CH:8]=1

참가 물질

4

반응물 2

HCID 69401Einecs 211-027-4HCID 594930653-Methoxy-indeno[1,2-b]pyridin-5-one

생성물 1

HCID 594925083-Hydroxy-indeno[1,2-b]pyridin-5-one수율 10.6%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
180 °C

실험 절차

Under an argon atmosphere, 3-methoxy-indeno[1,2-b]pyridin-5-one (0.545 g) and pyridinium chloride (5.89 g) were mixed with pyridine (1.0 ml). The reaction mixture was stirred with heating at 180° C. for 30 min while evaporating pyridine, and further stirred with heating at 200° C. for 4 hr. The mixture was cooled to room temperature, water was added and the mixture was stirred for 30 min. This slurry was filtered, and the obtained solid was dried under reduced pressure to give the title compound (0.054 g). The obtained solid was used for the next reaction without further purification.

후처리

  1. customwhile evaporating pyridine
  2. stirringfurther stirred
  3. temperaturewith heating at 200° C. for 4 hr
  4. temperatureThe mixture was cooled to room temperature
  5. additionwater was added
  6. stirringthe mixture was stirred for 30 min
  7. filtrationThis slurry was filtered
  8. customthe obtained solid was dried under reduced pressure

출처 및 근거

ORD 기록
ord-f428e289ddec4cc284fdab8226f447db
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871934B2

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