Methyl 3-(N'-hydroxycarbamimidoyl)-4-methylbenzoate → Methyl 3-carbamimidoyl-4-methylbenzoate

HRID 541185노트

반응식

HRID 541185 반응식
O[N:2]=[C:3]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:8]([O:10][CH3:11])=[O:9])[NH2:4]>CO>[C:3]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:8]([O:10][CH3:11])=[O:9])(=[NH:2])[NH2:4]

참가 물질

3

반응물 1

HCID 86672520Methyl 3-(N'-hydroxycarbamimidoyl)-4-methylbenzoate2회

생성물 1

HCID 68288326Methyl 3-carbamimidoyl-4-methylbenzoate수율 57%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

A round-bottom flask, containing a solution of methyl 3-(N′-hydroxycarbamimidoyl)-4-methylbenzoate (compound 1.8, 8 g, 36.50 mmol, 1.00 equiv, 95%) in methanol (150 mL) was purged with nitrogen gas. To the solution was added palladium on carbon (9 g, 10%, 60% water) and the flask was then further purged with nitrogen gas. The atmosphere was then changed to hydrogen and the mixture was stirred overnight at 25° C. under a balloon. After purging the system with nitrogen, the solids were removed by filtration and the filtrate was concentrated under reduced pressure to yield 4 g (54%) of the title compound as a brown solid.

후처리

  1. customwas purged with nitrogen gas
  2. additionTo the solution was added palladium on carbon (9 g, 10%, 60% water)
  3. customthe flask was then further purged with nitrogen gas
  4. customAfter purging the system with nitrogen
  5. customthe solids were removed by filtration
  6. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ce747048371c4dd2a007705e0ff13e67
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871790B2

반응 노트

불러오는 중…