5-Nitro-2-(1-pyrrolidinyl)pyridine → 6-(Pyrrolidin-1-yl)pyridin-3-amine

HRID 541221

반응식

HRID 541221 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:8][CH:9]=1)([O-])=O>C(O)C>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1

참가 물질

3

반응물 1

HCID 3168235-Nitro-2-(1-pyrrolidinyl)pyridine2회

생성물 1

HCID 38991726-(Pyrrolidin-1-yl)pyridin-3-amine수율 98%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Around-bottom flask, containing a solution of 5-nitro-2-(pyrrolidin-1-yl)pyridine (compound 40.1, 1.93 g, 10.00 mmol, 1.00 equiv) in ethanol (30 mL) was purged with nitrogen. Palladium on carbon (0.4 g, 10%, 60% water) was added. After further purging the system with nitrogen, the atmosphere was changed to hydrogen and the resulting mixture was stirred overnight at room temperature. After purging the system with nitrogen, the solids were filtered off and the filtrate was concentrated under reduced pressure and dried to yield 1.6 g (98%) of the title compound as a brown solid.

후처리

  1. customwas purged with nitrogen
  2. additionPalladium on carbon (0.4 g, 10%, 60% water) was added
  3. customAfter further purging the system with nitrogen
  4. customAfter purging the system with nitrogen
  5. filtrationthe solids were filtered off
  6. concentrationthe filtrate was concentrated under reduced pressure
  7. customdried

출처 및 근거

ORD 기록
ord-08683304d07f4398a320d3dacf0cb6e4
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871790B2

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