Dimethylamine → 2-hydrazinyl-N,N-dimethyl-2-oxoacetamide

HRID 541253노트

반응식

[NH:1]([C:3](=[O:9])[C:4](OCC)=[O:5])[NH2:2].[CH3:10][NH:11][CH3:12]>>[NH:1]([C:3](=[O:9])[C:4]([N:11]([CH3:12])[CH3:10])=[O:5])[NH2:2]

참가 물질

반응물 2

HCID 674Dimethylamine

HCID 2786935Ethyl 2-hydrazinyl-2-oxoacetate2회

생성물 1

HCID 431641122-hydrazinyl-N,N-dimethyl-2-oxoacetamide수율 76%

반응 조건

온도: 70 °C

실험 절차

To a round-bottom flask was added ethyl 2-hydrazinyl-2-oxoacetate (compound 134.1, 2.00 g, 13.6 mmol, 1.00 equiv, 90%). Dimethylamine (10 mL) was added to the reaction, and then the reaction was stirred overnight at 70° C. in an oil bath. The mixture was cooled to room temperature and concentrated in vacuo to yield 1.50 g (76%) of the title compound as a colorless oil.

후처리

temperatureThe mixture was cooled to room temperature
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-3777d09991874eea86164fa3917c9335
출처 데이터셋: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08871790B2

반응 노트

불러오는 중…