3-Methoxypropanehydrazide → HCID 178494843, 화합물

HRID 541319노트

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HRID 541319 반응식
C(S[N:4]=[CH:5][C:6]1[C:7]([CH:17]([CH3:19])[CH3:18])=[CH:8][C:9]([CH3:16])=[C:10]([CH:15]=1)[C:11]([O:13][CH3:14])=[O:12])C.[CH3:20][O:21][CH2:22][CH2:23][C:24]([NH:26][NH2:27])=O>C(O)(=O)C>[CH:17]([C:7]1[C:6]([C:5]2[NH:4][C:24]([CH2:23][CH2:22][O:21][CH3:20])=[N:26][N:27]=2)=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([CH3:16])[CH:8]=1)([CH3:18])[CH3:19]

참가 물질

4

반응물 2

HCID 27597273-Methoxypropanehydrazide2회HCID 86672536Methyl 5-((ethylthio)(imino)methyl)-4-isopropyl-2-methylbenzoate2회

생성물 1

HCID 178494843HCID 178494843, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
80 °C

실험 절차

Methyl 5-((ethylthio)(imino)methyl)-4-isopropyl-2-methylbenzoate (compound 198.4, 33 mg, 0.12 mmol, 1.0 equiv), 3-methoxypropanehydrazide (compound 143.1, 21 mg, 0.18 mmol, 1.5 equiv) and acetic acid (1.2 mL) were added to a 4-mL vial and heated at 80° C. with a loose cap for 4 hours. The solvent was removed in vacuo and the residue was dissolved in DCM (10 mL) and washed with saturated NaHCO3 (5 mL) then brine (5 mL), dried (Na2SO4), filtered and evaporated to a colorless oil (theoretical yield). m/z (ES+) 318 (M+H)+.

후처리

  1. customa loose cap for 4 hours
  2. customThe solvent was removed in vacuo
  3. dissolutionthe residue was dissolved in DCM (10 mL)
  4. washwashed with saturated NaHCO3 (5 mL)
  5. dry with materialbrine (5 mL), dried (Na2SO4)
  6. filtrationfiltered
  7. customevaporated to a colorless oil (theoretical yield)

출처 및 근거

ORD 기록
ord-646c84b34c3042069b81d5fe9249e604
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871790B2

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