Sodium Iodide → t-Butyl methyl 7-iodoheptylmalonate

HRID 5414

반응식

HRID 5414 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([C:17]([O:19][CH3:20])=[O:18])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11].[I-:21].[Na+]>CC(C)=O>[I:21][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([C:17]([O:19][CH3:20])=[O:18])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 19930816t-Butyl methyl 7-bromoheptylmalonate

생성물 1

HCID 19930825t-Butyl methyl 7-iodoheptylmalonate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

t-Butyl methyl 7-bromoheptylmalonate (8.81 g, 25.1 mmol) is dissolved in acetone (50 ml). Sodium iodide (3.7 g, 25.1 mmol) is added and the mixture is stirred at reflux for 2 hours. The reaction mixture is filtered and the filtrate is concentrated to dryness. The residue is dissolved in methylene chloride and filtered again. The filtrate is concentrated to dryness to give t-butyl methyl 7-iodoheptylmalonate as an oil.

후처리

  1. temperatureat reflux for 2 hours
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate is concentrated to dryness
  4. dissolutionThe residue is dissolved in methylene chloride
  5. filtrationfiltered again
  6. concentrationThe filtrate is concentrated to dryness

출처 및 근거

ORD 기록
ord-2f96668fb4f34f4cb203add2e1dbf0d7
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244889

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