Ethyl Acetate → Tert-butyl 4-(4-cyanophenyl)-2-oxopiperidine-1-carboxylate

HRID 541415노트

반응식

HRID 541415 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:2].C(OCC)(=[O:24])C>O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C:13](=[O:24])[CH2:14]2)=[CH:7][CH:8]=1)#[N:2]

참가 물질

4

반응물 2

HCID 8857Ethyl AcetateHCID 22492960Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate2회

생성물 1

HCID 68352653Tert-butyl 4-(4-cyanophenyl)-2-oxopiperidine-1-carboxylate수율 80%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into a round-bottom flask, was placed a solution of tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (compound 1.4, 515 mg, 1.80 mmol, 1.00 equiv) in ethyl acetate (5 mL). A solution of NaIO4 (963 mg, 4.50 mmol, 2.50 equiv) in water (5 mL) and RuCl3 (74.7 mg, 0.36 mmol, 0.20 equiv) was carefully added. The resulting mixture was stirred overnight at room temperature. The solids were removed by filtration and the filtrate was washed with 2×20 mL of water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to yield 432 mg (80%) of the title compound as a light yellow oil.

후처리

  1. customInto a round-bottom flask, was placed
  2. customThe solids were removed by filtration
  3. washthe filtrate was washed with 2×20 mL of water
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7972df5baf824fe190460f9bef425ecc
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871790B2

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