Nitric Acid → HCID 178433475, 화합물

HRID 541419노트

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HRID 541419 반응식
[OH:1][C:2]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[OH:1][C:2]1[N:10]=[C:9]([CH3:11])[C:8]([N+:12]([O-:14])=[O:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 178425908HCID 178425908, 화합물

생성물 1

HCID 178433475HCID 178433475, 화합물수율 87.2%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

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온도
90 °C

실험 절차

To a solution of 2-hydroxy-6-methylnicotinic acid (14.0 g, 91.5 mmol, 1.00 equiv) in sulfuric acid (conc.) (140 mL) at 0° C. was added dropwise a solution of HNO3 (12.0 g, 190 mmol, 2.00 equiv) in sulfuric acid (conc.) (10 mL). The resulting mixture was then stirred for 2 h at 90° C., cooled to ambient temperature, and then quenched with 250 mL of ice water. The resulting solids were collected by filtration and dried in an oven under reduced pressure to yield 15.8 g (87%) of the title compound as a yellow solid.

후처리

  1. temperaturecooled to ambient temperature
  2. customquenched with 250 mL of ice water
  3. filtrationThe resulting solids were collected by filtration
  4. customdried in an oven under reduced pressure

출처 및 근거

ORD 기록
ord-e5cf01cd3b4b4d03b11cb49e81b5cb2e
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871790B2

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