2-Chlorothiazole → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(1,3-thiazol-2-yl)piperidin-4-yl]acetamide tris(trifluoroacetate)

참여 물질

역할	이름	HCID	투입량
반응물	2-Chlorothiazole	HCID 76429	—
반응물	N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate)	HCID 86636131	—
생성물	N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(1,3-thiazol-2-yl)piperidin-4-yl]acetamide tris(trifluoroacetate)	HCID 86636206	12%

반응 단계

The desired compound was prepared according to the procedure of Example A157, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 2-chloro-1,3-thiazole as starting materials in 12% yield. LCMS for C27H28ClN8OS (M+H)+: m/z=547.2.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08871753B2
출처 데이터셋	uspto-grants-2014_10
ORD ID	ord-3d93ef87ae4d4660949375f095894269
출처 메모	uspto-grants-2014_10