3-Methyl-2-furoic acid → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(3-methyl-2-furoyl)piperidin-4-yl]acetamide bis(trifluoroacetate)

참여 물질

역할	이름	HCID	투입량
반응물	3-Methyl-2-furoic acid	HCID 78127	—
반응물	N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate)	HCID 86636208	—
생성물	N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(3-methyl-2-furoyl)piperidin-4-yl]acetamide bis(trifluoroacetate)	HCID 86636209	51%

반응 단계

The desired compound was prepared according to the procedure of Example A27, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and 3-methyl-2-furoic acid as starting materials in 51% yield. LCMS for C30H31ClN7O3 (M+H)+: m/z=572.2.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08871753B2
출처 데이터셋	uspto-grants-2014_10
ORD ID	ord-499d78d444024097af68af7f70f2f2ed
출처 메모	uspto-grants-2014_10