Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromoacetic Acid → 7-(Chloroacetyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromoacetic Acid | HCID 6227 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride | HCID 11961371 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 7-(Chloroacetyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine | HCID 57962294 | 33% |
반응 단계
Bromoacetic acid (300 mg, 2.2 mmol) and 3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (490 mg, 2.2 mmol) were stirred in dichloromethane (5 mL) with N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (412 mg, 2.2 mmol) and N,N-diisopropylethylamine (560 mL, 3.2 μmol) for 3 hours at rt. The mixture was washed with water, dried over sodium sulfate and evaporated to give the desired compound in 33% yield. LCMS for C8H8ClF3N4O (M+H)+: m/z=269.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08871753B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-436f68b65c2443939f419eab38d75050 |
| 출처 메모 | uspto-grants-2014_10 |