HCID 57962249, 화합물 → tert-Butyl (3-{[(3-aminophenyl)acetyl]amino}phenyl)carbamate

HRID 541835노트

반응식

HRID 541835 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH:17]=[CH:18][CH:19]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:24])[CH3:26])[CH:17]=[CH:18][CH:19]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 57962249HCID 57962249, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 57962170tert-Butyl (3-{[(3-aminophenyl)acetyl]amino}phenyl)carbamate수율 94%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of tert-butyl (3-{[(3-nitrophenyl)acetyl]amino}phenyl)carbamate (0.35 g, 0.94 mmol) in methanol (100 mL) was added 10% palladium on carbon (1:10, Palladium:carbon black, 0.15 g, 0.13 mmol). The reaction was shaken under 60 psi hydrogen gas overnight. The crude mixture was filtered through celite and concentrated under vacuum to give the desired product (0.30 g, 94%). LCMS for C19H23N3O3 (M-tBu+H)+: m/z=286.0.

후처리

  1. filtrationThe crude mixture was filtered through celite
  2. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-270278be8ca946d49928fcfffd8b94e5
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871753B2

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