HCID 57961596, 화합물 → tert-Butyl {2-[2-(3-aminophenyl)ethyl]pyridin-4-yl}carbamate

HRID 541842노트

반응식

HRID 541842 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[C:14]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1>CO.[Pd]>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[C:14]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[CH:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 57961596HCID 57961596, 화합물

생성물 1

HCID 57962008tert-Butyl {2-[2-(3-aminophenyl)ethyl]pyridin-4-yl}carbamate수율 95%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a mixture of tert-butyl {2-[(3-aminophenyl)ethynyl]pyridin-4-yl}carbamate (250 mg, 1.62 mmol) (prepared in Example C12, step A) in methanol (10 mL) was added 10% palladium on carbon (0.30 g, 0.24 mmol). The reaction mixture was hydrogenated at 50 psi overnight. The resultant mixture was filtered and concentrated to provide the desired product (240 mg, 95%) as a white solid. LCMS for C18H24N3O2 (M+H)+: m/z=314.0.

후처리

  1. customwas hydrogenated at 50 psi overnight
  2. filtrationThe resultant mixture was filtered
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9260dea853494d6cb6f944618256c05a
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871753B2

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