Water → Methyl 3-aminopyrazinecarboxylate
반응식
[NH2:1][C:2]1[C:3]([C:8]([OH:10])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.S(=O)(=O)(O)O.O.[C:17](=O)(O)[O-].[Na+]>CO>[NH2:1][C:2]1[C:3]([C:8]([O:10][CH3:17])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1참가 물질
6
실험 절차
3-Aminopyrazine-2-carboxylic acid (55.5 g, 0.4 mol) is suspended in 400 mL of methanol, cooled in an ice bath and concentrated sulfuric acid (80 mL) is gradually added with stirring and stirring then continued for 48 hours at room temperature. The resulting dark brown solution is poured into 700 mL of water containing sodium bicarbonate (160 g). The brown crystalline solid which precipitates is collected and dried. The crude product is purified by recrystallization from water to yield the product as yellow needles in 63% yield, melting point 169°-170° C.
후처리
- temperaturecooled in an ice bath
- stirringstirring
- customThe brown crystalline solid which precipitates
- customis collected
- customdried
- customThe crude product is purified by recrystallization from water
출처 및 근거
- ORD 기록
- ord-68e3a5907b6a46749902e095f4074eb3
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05622913
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