2-(3-Nitrophenoxy)tetrahydro-2H-pyran → HCID 12046288, 화합물
반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[O:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][O:9]1)([O-])=O>CO.[Pd]>[O:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH:8]1[O:7][C:6]1[CH:5]=[C:4]([CH:16]=[CH:15][CH:14]=1)[NH2:1]참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
A solution of 2-(3-nitrophenoxy)tetrahydro-2H-pyran (1.0 g, 4.5 mmol) in methanol (13 mL) was degassed with nitrogen (3×) and treated with 10% Pd/C (wet Degussa type) (12 mg). The reaction mixture was degassed and stirred under an atmosphere of hydrogen at 25° C. for 2 h. The reaction mixture was filtered to give the desired product (0.87 g, quantitative) as a tan oil. LCMS for C11H16NO2 (M+H)+: m/z=194.0.
후처리
- customThe reaction mixture was degassed
- filtrationThe reaction mixture was filtered
출처 및 근거
- ORD 기록
- ord-e0b2a93eb9534ea9a930acff14c00403
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08871753B2
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