Allyl bromide → Ethyl 2,6-bis(trifluoromethyl)-4-allyloxy-3-pyridinecarboxylate
반응식
[F:1][C:2]([F:20])([F:19])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([OH:14])[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1.C([O-])([O-])=O.[K+].[K+].[CH2:27](Br)[CH:28]=[CH2:29]>CC(C)=O>[F:20][C:2]([F:19])([F:1])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([O:14][CH2:29][CH:28]=[CH2:27])[CH:6]=[C:5]([C:15]([F:18])([F:17])[F:16])[N:4]=1참가 물질
5
실험 절차
A mixture of 6.06 g (0.02 mol) of product of Example 3, 2.8 g (0.02 mol) of K2CO3, 30 g of allyl bromide, and 50 ml of acetone was held at reflux for 4 hours and concentrated. The residue was treated with water and extracted into ether. The ether solution was dried and concentrated. The residue was kugelrohr distilled at 133 Pa (pot temperature 110° C.) to give 6.2 g (90%) of product, nD25 1.4330.