Benzene → 1-[Bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

HRID 542191

반응식

HRID 542191 반응식
[CH2:1]=[O:2].C1C=CC=CC=1.[CH3:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[CH2:13][CH2:12][N:11]=1.C[CH2:25][O-:26].[Na+]>>[OH:2][CH2:1][CH:9]([CH2:25][OH:26])[C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[CH2:13][CH2:12][N:11]=1

참가 물질

5

반응물 4

HCID 241BenzeneHCID 712FormaldehydeHCID 226523,4-Dihydro-6,7-dimethoxy-1-methylisoquinolineHCID 2723922Sodium ethoxide

생성물 1

HCID 136966801-[Bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

실험 절차

To a solution of 2.5 moles of paraformaldehyde in 500 ml. of benzene 1 mole (205.3 g) of 1-methyl-6,7-dimethoxy-3,4-dihydroisoquinoline and subsequently freshly prepared sodium ethylate (1 g sodium+50 ml ethanol) are added at room temperature, with stirring. The reaction mixture is refluxed for 4 hours. The mixture is then evaporated under reduced pressure, and the obtained crystalline material is recrystallized from a mixture of acetone and ether. The aimed compound is obtained which has the same melting point as the product prepared in Example 1.

후처리

  1. temperatureThe reaction mixture is refluxed for 4 hours
  2. customThe mixture is then evaporated under reduced pressure
  3. customthe obtained crystalline material is recrystallized from a mixture of acetone and ether

출처 및 근거

ORD 기록
ord-275bef7252a34716816043ec5c21bea5
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04656179

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