Indole-3-Acetic Acid → trans-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-1H-indole-3-acetamide monohydrochloride

HRID 542213

반응식

HRID 542213 반응식
[CH3:1][NH:2][C@@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]1[N:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1.[NH:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([CH2:23][C:24](O)=[O:25])=[CH:15]1.S(Cl)([Cl:29])=O.CCOCC>C(Cl)Cl>[ClH:29].[CH3:1][N:2]([C@@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]1[N:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)[C:24](=[O:25])[CH2:23][C:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:14][CH:15]=1

참가 물질

6

반응물 4

HCID 802Indole-3-Acetic AcidHCID 3283Diethyl EtherHCID 24386Thionyl ChlorideHCID 13377463Cyclohexanamine, N-methyl-2-(1-pyrrolidinyl)-, trans-

생성물 1

HCID 70352298trans-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-1H-indole-3-acetamide monohydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Trans-N-methyl-2-(1-pyrrolidinyl)cyclohexanamine (0.368 g) was dissolved in methylene chloride (10 ml) and stirred at room temperature. The acid chloride of 3-indole acetic acid (prepared by the action of thionyl chloride on 3-indole acetic acid, 0.35 g) dissolved in methylene chloride (10 ml) was added and let stand for five hours. Ether was added to rapidly stirred solution until no more precipitate appeared. After further rapid stirring for one hour, the precipitate was filtered and dried in a vacuum oven at 90° C. for one hour and stored in a predried bottle. The product was in the form of a black glassy solid (300 mg).

후처리

  1. additionwas added
  2. stirringAfter further rapid stirring for one hour
  3. filtrationthe precipitate was filtered
  4. customdried in a vacuum oven at 90° C. for one hour

출처 및 근거

ORD 기록
ord-cbfb82d7941c46abb4d7a72f6132adf3
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04656182

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