Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diazomethane diethylether → methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diazomethane diethylether | HCID 21186548 | — |
| 반응물 | methyl 1-(4-aminosulfonylphenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate | HCID 70401818 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate | HCID 67583673 | 29% |
반응 단계
A solution of 4a (100 mg) in methanol (20 ml) was treated with excess diazomethane ether solution to give two products. They are separated via preparative tlc using 1500 μm silica gel plates developed 3 times with 5% ethyl acetate in chloroform to give Z methyl 1-(4-(N-methylaminosulfonyl)phenyl)methylene-5-methoxy-2-methyl-1H-3-indenylacetate (6a) (30 mg, 29% yield): m.p. 167°-169° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04656190 |
| 출처 데이터셋 | uspto-grants-1987_04 |
| ORD ID | ord-444feaece30a4ad5bb8930ec7d2f63d3 |
| 출처 메모 | uspto-grants-1987_04 |