Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl (5-fluoro-2-methyl-1H-inden-3-yl)acetate → 5-fluoro-2-methyl-1H-3-indenyl-(2-hydroxy) ethane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl (5-fluoro-2-methyl-1H-inden-3-yl)acetate | HCID 15434585 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-fluoro-2-methyl-1H-3-indenyl-(2-hydroxy) ethane | HCID 13933293 | 71.1% |
반응 단계
To a solution of 14b (24 g) in dry THF (300 ml), LiAlH4 (6.9 g) was added in portions. The mixture was stirred at room temperature for 1.5 hours. Excess LiAlH4 (LAH) was destroyed with saturated Na2SO4 solution. The organic phase was concentrated in vacuo, and the crude product was purified via silica gel column chromatography eluting with methylene chloride. The product was recrystallized from hexane to give 5-fluoro-2-methyl-1H-3-indenyl-(2-hydroxy)ethane (15b) (14.9 g, 63% yield): m.p. 65°-66.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04656190 |
| 출처 데이터셋 | uspto-grants-1987_04 |
| ORD ID | ord-caf1133566164e30834c0c7c92913eaf |
| 출처 메모 | uspto-grants-1987_04 |