Benzamidine, hydrochloride → HCID 10638748, 화합물

HRID 54223

반응식

HRID 54223 반응식
Cl.C(N)(=N)C1C=CC=CC=1.Br[C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:23]=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=3)[CH:21]=[CH:20][N:19]=2)=[CH:14][CH:13]=1>>[C:15]1([C:18]2[N:23]=[C:22]([C:24]3[CH:25]=[CH:26][C:27]([Br:30])=[CH:28][CH:29]=3)[CH:21]=[CH:20][N:19]=2)[CH:14]=[CH:13][CH:12]=[CH:17][CH:16]=1

참가 물질

3

반응물 2

HCID 80289Benzamidine, hydrochlorideHCID 10739118Pyrimidine, 2,4-bis(4-bromophenyl)-

생성물 1

HCID 10638748HCID 10638748, 화합물수율 72%

실험 절차

Benzamidine hydrochloride (4.7 g, 0.03 mole) and 1-dimethylamino-3-dimethylimonio-1-(4-bromophenyl)-1-propene perchlorate are allowed to react as described above in Example 4 for the preparation of 2,4-Bis(4-bromophenyl)-pyrimidine. After work-up and recrystallization from CHCl3 :ethyl ether (1:3), 7.2 g (72%) of a white crystalline solid is obtained which melted at 107°-08° C. IR(KBr) 2925, 1597, 1562, 1540, 1427 cm-1. 1H-NMR: (CDCl3) 8.65 (d, 1H, j=5.3 Hz), 8.55-8.52 (m, 2H), 8.02 (d, 2H, j=8.3 Hz), 7.6 (d, 2H, j=8.8 Hz), 7.5-7.46 (m, 3H), 7.44 (d, 1H, j=5.3 Hz). 13C-NMR (CDCl3): 164.6, 162.5, 157.9, 137.6, 135.7, 132.1, 130.8, 128.6, 128.5, 128.2, 125.6, 114.1. MS m/e: 311 (M+).

후처리

  1. customto react
  2. customAfter work-up and recrystallization from CHCl3 :ethyl ether (1:3)

출처 및 근거

ORD 기록
ord-0ce5dc0ab00540e5906c8723dae3842a
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622955

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