Ethanol → 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-ethylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
반응식
[N+:1]([C:4]1[CH:5]=[C:6](C=C[CH:30]=1)[CH:7]=[CH:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:27])[CH3:26])=[CH:20][CH:19]=1)=[O:13])=O)([O-:3])=[O:2].[NH2:31]/[C:32](/[CH3:42])=[CH:33]\[C:34]([O:36][CH2:37][CH2:38][S:39][CH2:40][CH3:41])=[O:35].[CH2:43](O)[CH3:44]>>[CH3:43][C:44]1[NH:31][C:32]([CH3:42])=[C:33]([C:34]([O:36][CH2:37][CH2:38][S:39][CH2:40][CH3:41])=[O:35])[CH:9]([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:30]=2)[C:11]=1[C:12]([O:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([NH:24][C:25](=[O:27])[CH3:26])=[CH:22][CH:23]=1)=[O:13]참가 물질
4
반응 조건
- 온도
- -5 °C
실험 절차
15 g (0.04 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 6.88 g (0.04 moles) of 2-ethylthioethyl 3-aminocrotonate were heated under reflux in 35 ml of ethanol for 8 hours. The solution was then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-ethylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as a yellow powder melting--after recrystallisation in ethanol--at 100°-104° C. The yield is 60% of the theoretical yield.
출처 및 근거
- ORD 기록
- ord-ceddbf234db34e629fec1ff9ba7458c2
- 출처 데이터셋
- uspto-grants-1987_04
- 특허 번호
- US04656181
반응 노트
불러오는 중…