참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Butylurea | HCID 11595 | — |
| 반응물 | N-Nitroaniline | HCID 61191 | — |
| 반응물 | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N-butyl-N'-(beta-D-glucosyl)-N-nitrosourea | HCID 13346001 | 669.7% |
반응 단계
A mixture of 3.6 g of D-glucose, 2.8 g of butylurea, 0.2 g of nitroaniline and 0.15 ml of a concentrated hydrochloric acid in 10 ml of methanol is heated at reflux for 20 minutes. The resulting precipitate in the amount of 3 g is separated and added with 15 ml of glacial acetic acid, 10 ml of distilled water, 1.8 g of sodium nitrite and stirred at the temperature of -1° C. for 2 hours to give 2.98 g of the product (90% of the thoretical), hydroscopic, [α]D -1° (CH3OH), Rf =0.85. Found, %: N 13.47. Calculated, % N 13.68.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04656259 |
|---|
| 출처 데이터셋 | uspto-grants-1987_04 |
|---|
| ORD ID | ord-7d9ad15dac5d4f31933a8a05d57d8313 |
|---|
| 출처 메모 | uspto-grants-1987_04 |
|---|
