2-Bromo-2-phenylacetaldehyde → p-Nitroacetophenone

HRID 542278노트

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HRID 542278 반응식
BrC[C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]([C:14]1C=CC([N+]([O-])=O)=CC=1CBr)=[O:13].BrC(C1C=CC=CC=1)C=O>>[N+:9]([C:7]1[CH:6]=[CH:5][C:4]([C:12](=[O:13])[CH3:14])=[CH:3][CH:8]=1)([O-:11])=[O:10]

참가 물질

3

반응물 2

HCID 108889012-Bromo-2-phenylacetaldehydeHCID 86741403Bromomethyl-p-nitro-phenyl-ketone

생성물 1

HCID 7487p-Nitroacetophenone수율 98%

실험 절차

One proceeds according to Example 14 but bromomethyl-p-nitro-phenyl-ketone is used as starting material in the place of α-bromo-α-phenyl-acetaldehyde. The reaction mixture is not worked up by the extraction method according to Example 14 but by precipitating the product with 50 ml of water, filtering off the same and washing it three times with 20 ml of water each. Thus 16.1 g of the desired compound are obtained, yield 98%.

후처리

  1. extractionThe reaction mixture is not worked up by the extraction method
  2. customby precipitating the product with 50 ml of water
  3. filtrationfiltering off the same and
  4. washwashing it three times with 20 ml of water each

출처 및 근거

ORD 기록
ord-da7cefb13510455987f10dbb2632f5d7
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04656290

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