참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenediamine | HCID 3301 | — |
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 2,6-dichlorobenzenesulfonic Acid | HCID 4051324 | — |
| 생성물 | Clonidine | HCID 2803 | — |
반응 단계
2,6-dichlorophenylsulfonic acid (1.0 g, 0.0037 m) was added to ethylenediamine (0.5 g, 0.008 m) in the absence of solvent. The reaction exothermed to 35° C. and was diluted with acetonitrile and heated at 65° C. for 7.25 hr. The reaction was concentrated, treated with sodium hydroxide and extracted with methylene chloride. The organic phase was dried and concentrated to yield 0.5 g of clonidine. The product was identified by spectroscopic methods.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04656291 |
|---|
| 출처 데이터셋 | uspto-grants-1987_04 |
|---|
| ORD ID | ord-a6f8964ffc3341fca1c328b0030d7bf8 |
|---|
| 출처 메모 | uspto-grants-1987_04 |
|---|
