5-(4-Nitrophenyl)pyrazin-2(1H)-one → 5-(4-Aminophenyl)pyrazin-2(1H)-one

HRID 542456

반응식

HRID 542456 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Pd].CN(C)C=O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=2)=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 138535735-(4-Nitrophenyl)pyrazin-2(1H)-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 123580285-(4-Aminophenyl)pyrazin-2(1H)-one수율 81.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6228Dimethylformamide용매

실험 절차

5-(4-Nitrophenyl)-2-(1H)-pyrazinone (0.1 g) was hydrogenated over 10% Palladium on Charcoal (0.01 g) at atmospheric pressure in 50% aqueous dimethylformamide containing 2N sodium hydroxide (0.46 ml). Once the theoretical quantity of hydrogen uptake had been observed, the reaction mixture was filtered and the filtrate treated with HCl to pH6 and evaporated. Trituration of the residue with water afforded the title compound 0.07 g, m.p. 269°-271.5° C. (with decomposition).

후처리

  1. filtrationthe reaction mixture was filtered
  2. additionthe filtrate treated with HCl to pH6
  3. customevaporated

출처 및 근거

ORD 기록
ord-9ea8fa7432e44b85bfda7e7ceeebd41a
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04657906

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