Potassium Carbonate → 2-isopropylamino-5-methyl-4H-3,1-benzoxazin-4-one
반응식
Cl.[CH:2]([NH:5][C:6]1[O:11][C:10](=[O:12])[C:9]2[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:8]=2[N:7]=1)([CH3:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH:2]([NH:5][C:6]1[O:11][C:10](=[O:12])[C:9]2[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:8]=2[N:7]=1)([CH3:4])[CH3:3]참가 물질
4
실험 절차
1.0 g of 2-isopropylamino-5-methyl-4H-3,1-benzoxazin-4-one HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 2-isopropylamino-5-methyl-4H-3,1-benzoxazin-4-one as the free base.
후처리
- dissolutionis completely dissolved
- customThe organic layer is then separated
- washwashed twice with water
- dry with materialdried over magnesium sulfate
- customevaporated
출처 및 근거
- ORD 기록
- ord-c2c5a0de98144dba954e5555c74c2695
- 출처 데이터셋
- uspto-grants-1987_04
- 특허 번호
- US04657893
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