Hydrogen iodide → 4-Iodo-6-methoxypyrimidin-2-amine

HRID 542656노트

반응식

HRID 542656 반응식
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1.[IH:11]>O.C(=O)([O-])[O-].[K+].[K+]>[NH2:1][C:2]1[N:7]=[C:6]([I:11])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1

참가 물질

5

반응물 2

HCID 24841Hydrogen iodideHCID 798112-Pyrimidinamine, 4-chloro-6-methoxy-

생성물 1

HCID 138244654-Iodo-6-methoxypyrimidin-2-amine

시약·촉매·용매 2

HCID 962Water용매HCID 11430Potassium Carbonate용매

실험 절차

18.0 g of 2-amino-4-chloro-6-methoxypyrimidine was added to 65 mL of 57% aqueous hydroiodic acid with ice bath cooling. The resulting thick mixture was kept at ambient temperature for 65 hours, diluted with water and neutralized with potassium carbonate. The solid was collected and recrystallized from aqueous ethanol to give 5.0 g of white crystals, m.p. 141.5°-144° C.

후처리

  1. temperaturecooling
  2. customThe solid was collected
  3. customrecrystallized from aqueous ethanol

출처 및 근거

ORD 기록
ord-a3ee4e4c332e4672a411cc41f630d79b
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04659361

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