Benzoic acid, 2-(isocyanatosulfonyl)-, methyl ester → HCID 13824466, 화합물

HRID 542657노트

반응식

HRID 542657 반응식
[NH2:1][C:2]1[N:7]=[C:6]([I:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1.[C:11]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22])([O:13][CH3:14])=[O:12]>C(Cl)Cl>[I:8][C:6]1[CH:5]=[C:4]([O:9][CH3:10])[N:3]=[C:2]([NH:1][C:25]([NH:24][S:21]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[C:11]([O:13][CH3:14])=[O:12])(=[O:23])=[O:22])=[O:26])[N:7]=1

참가 물질

4

반응물 2

HCID 156281Benzoic acid, 2-(isocyanatosulfonyl)-, methyl esterHCID 138244654-Iodo-6-methoxypyrimidin-2-amine

생성물 1

HCID 13824466HCID 13824466, 화합물수율 20.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 0.25 g of 2-amino-4-iodo-6-methoxypyrimidine in 5 mL of dry methylene chloride was added 0.30 g 2-carbomethoxybenzenesulfonyl isocyanate. The resulting solution was allowed to stand for 20 hours at ambient temperature. The solution was cooled in an ice bath and crystallization induced with scratching. The crystals were collected, washed with n-butylchloride and dried to afford 0.10 g of the title compound, m.p. b 194°-196° C. (dec).

후처리

  1. temperatureThe solution was cooled in an ice bath
  2. customcrystallization
  3. customThe crystals were collected
  4. washwashed with n-butylchloride
  5. customdried

출처 및 근거

ORD 기록
ord-1cb89b47bfd947bcb3453fe73b8772ec
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04659361

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