Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tris(furan-2-yl)phosphane → 2,4-Diamino-6-methyl-5-[1-fluoro-3-methyl-3-(4-chlorophenyl)-1-butenyl]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tris(furan-2-yl)phosphane | HCID 521585 | — |
| 반응물 | 5-Iodo-6-methylpyrimidine-2,4-diamine | HCID 15855792 | — |
| 반응물 | 1-Fluoro-3-(4-chlorophenyl)-3-methyl-1-tributylstannyl-1-butene | HCID 67632345 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2,4-Diamino-6-methyl-5-[1-fluoro-3-methyl-3-(4-chlorophenyl)-1-butenyl]pyrimidine | HCID 54232355 | — |
반응 단계
This compound is prepared in a manner analogous to that of Step E of Example 4, using 1.2 grams (0.0048 mole) of 2,4-diamino-5-iodo-6-methylpyrimidine, 2.3 grams (0.0048 mole) of 1-fluoro-3-(4-chlorophenyl)-3-methyl-1-tributylstannyl-1-butene, 0.04 gram of tri-2-furylphosphine, 0.04 gram of tris(dibenzylidineacetone)dipalladium(0) in about 30 mL of N,N-dimethylformamide, yielding 2,4-diamino-6-methyl-5-[1-fluoro-3-methyl-3-(4-chlorophenyl)-1-butenyl]pyrimidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05622954 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-f7e0132fef5c4ba29f07494aaaf13849 |
| 출처 메모 | uspto-grants-1997_04 |