홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

m-Chloroperbenzoic acid → 1-[1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-oxo-1,4-dihydroquinolin-7-yl]piperidine 1-oxide monohydrate

HRID 542822
노트
인쇄 미리보기

반응식

HRID 542822 반응식
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=2)[C:5](=[O:18])[C:4]([C:19]2[N:23]([CH3:24])[N:22]=[N:21][N:20]=2)=[CH:3]1.ClC1C=CC=C(C(OO)=[O:33])C=1.C(=O)(O)[O-].[Na+]>ClCCl>[OH2:18].[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]3([O-:33])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=2)[C:5](=[O:18])[C:4]([C:19]2[N:23]([CH3:24])[N:22]=[N:21][N:20]=2)=[CH:3]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 70297m-Chloroperbenzoic acid2회HCID 516892Sodium BicarbonateHCID 134744311-methyl-3-(1-methyl-1H-tetrazol-5-yl)-7-piperidino-4-quinolone

생성물 1

HCID 202072491-[1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-oxo-1,4-dihydroquinolin-7-yl]piperidine 1-oxide monohydrate

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

To a stirred solution of the 4-quinolone of Example 30 (1.44 g) in dichloromethane (100 ml) was added a solution of 3-chloroperbenzoic acid (85%, 0.86 g) in dichloromethane (20 ml) and the mixture was stirred for 52 hours. A solution of 3-chloroperbenzoic acid (85%, 0.27 g) in dichloromethane (10 ml) was added and the mixture was stirred for 20 hours. Saturated aqueous sodium bicarbonate (40 ml) was added and the mixture was stirred for 45 minutes. The mixture was evaporated to dryness and the residue was extracted with dichloromethane (75 ml) for 1.5 hours using a Soxhlet apparatus. The extract was evaporated and the residue was crystallised from industrial methylated spirit:diethyl ether 4:1 to give 1-[1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-oxo-1,4-dihydroquinolin-7-yl]piperidine 1-oxide monohydrate, m.p. 163°-166°.

후처리

  1. stirringthe mixture was stirred for 20 hours
  2. stirringthe mixture was stirred for 45 minutes
  3. customThe mixture was evaporated to dryness
  4. extractionthe residue was extracted with dichloromethane (75 ml) for 1.5 hours
  5. customThe extract was evaporated
  6. customthe residue was crystallised from industrial methylated spirit:diethyl ether 4:1

출처 및 근거

ORD 기록
ord-474c1567ab174990867c79ae30cc4a6f
출처 데이터셋
uspto-grants-1987_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04659718

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트