Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium metaborate → 4-{N-[4-(3-nitrophenyl)-2-butyl]-aminomethyl}-2,2-dimethylchroman
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium metaborate | HCID 145326 | — |
| 반응물 | 2,2-Dimethyl-3,4-dihydro-2H-1-benzopyran-4-carbaldehyde | HCID 13537043 | — |
| 반응물 | 4-(3-Nitrophenyl)butan-2-amine | HCID 13537044 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-{N-[4-(3-nitrophenyl)-2-butyl]-aminomethyl}-2,2-dimethylchroman | HCID 13537045 | — |
반응 단계
12.1 g (0.1 mol) of 2-amino-4-(3-nitrophenyl)butane are added to 19.0 g (0.1 mol) of 2,2-dimethyl-4-formyl-chroman in 100 ml of methanol at 20° C., with stirring and slight cooling, and the mixture is stirred for 1.5 hours. Thereafter, 4.5 g of sodium boranate are added, and stirring is continued for 1 day, and the mixture is evaporated down and worked up with ethyl acetate/water. The ethyl acetate phase is washed with water, dried and evaporated down. Distillation gives 4-{N-[4-(3-nitrophenyl)-2-butyl]-aminomethyl}-2,2-dimethylchroman. B.p.: 225°-235° C./0.04 mmHg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04659737 |
| 출처 데이터셋 | uspto-grants-1987_04 |
| ORD ID | ord-551240f347614c54874b79a1bb7ff07d |
| 출처 메모 | uspto-grants-1987_04 |