Methanol → HCID 13084130, 화합물

HRID 543048

반응식

HRID 543048 반응식
[CH3:1]O.S(Cl)(Cl)=O.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[C:19]([CH3:20])=[CH:18][C:17](=[O:21])[C:16]([C:22]([OH:24])=[O:23])=[N:15]2)=[CH:10][CH:9]=1>O>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[C:19]([CH3:20])=[CH:18][C:17](=[O:21])[C:16]([C:22]([O:24][CH3:1])=[O:23])=[N:15]2)=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 197225Fenridazon

생성물 1

HCID 13084130HCID 13084130, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 100 ml of methanol, cooled to -5° C., there is added dropwise 11.9 g (0.1 mol) of thionyl chloride. Upon completion of the addition 13.23 g (0.05 mol) of 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-6-methylpyridazine-3-carboxylic Acid (see Example 12) is added. The suspension formed is vacuum filtered after stirring at room temperature for 3 hrs. to afford the product, mp 183°-193° C. decomp. Treatment of the product with water affords the Methyl 1-(4-chlorophenyl)-1,4-dihydro-4-oxo-6-methylpyridazine-3-carboxylate.

후처리

  1. additionis added
  2. customThe suspension formed
  3. filtrationfiltered
  4. customto afford the product, mp 183°-193° C. decomp

출처 및 근거

ORD 기록
ord-59c945fce7a74f389e3a98ca481f5395
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04661145

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