Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloromethyl benzoate → 3-(Dimethylcarbamoyloxy)-1-(phenylcarbonyloxymethyl)pyridinium chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloromethyl benzoate | HCID 79257 | — |
| 반응물 | Norpyridostigmine | HCID 98821 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-(Dimethylcarbamoyloxy)-1-(phenylcarbonyloxymethyl)pyridinium chloride | HCID 13881954 | 85.2% |
반응 단계
3-Dimethylcarbamoyloxypyridine (4.98 g) and chloromethylbenzoate (5.13 g) were heated to 70° C. with stirring for 4 hrs. The hot reaction mixture was poured into 100 ml of diethyl ether with vigorous stirring. The precipitated solids were filtered off and washed twice with anhydrous diethyl ether (100 ml×2). Recrystallization from acetone gave 8.6 g of 3-(dimethylcarbamoyloxy)-1-(phenylcarbonyloxymethyl)pyridinium chloride as prisms, m.p. 175°-176° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04661502 |
| 출처 데이터셋 | uspto-grants-1987_04 |
| ORD ID | ord-4fe42735981d4326ac1d16bf7b548e47 |
| 출처 메모 | uspto-grants-1987_04 |