Triethylamine → 1-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]propyl}-3-benzylurea dihydrochloride

HRID 543181

반응식

HRID 543181 반응식
[CH2:1]([N:8]=[C:9]=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:11].Cl.Cl.[NH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)[CH2:20][CH2:19]1.C(N(CC)CC)C>C(Cl)Cl>[ClH:31].[ClH:11].[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([CH2:24][N:21]2[CH2:20][CH2:19][N:18]([CH2:17][CH2:16][CH2:15][NH:14][C:9]([NH:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[O:10])[CH2:23][CH2:22]2)=[CH:26][CH:27]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 76639Benzyl isocyanateHCID 202057391-(3-Aminopropyl)-4-(4-chlorobenzyl)piperazine trihydrochloride

생성물 1

HCID 136066921-{3-[4-(4-Chlorobenzyl)piperazin-1-yl]propyl}-3-benzylurea dihydrochloride수율 154.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The procedure described in Example 21 was followed, using benzyl isocyanate (1.33 g; 10 mmole), 1-(3-aminopropyl)-4-(4-chlorobenzyl)piperazine trihydrochloride (3.77 g; 10 mmole), methylene chloride (250 ml) and triethylamine (4.3 ml; 31 mmole) to provide the title compound (3.65 g; 77% yield) as colorless crystals, m.p. 203°-206° C.

출처 및 근거

ORD 기록
ord-bd4e705de7984a19ab411ec262ebd57d
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04661481

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