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Potassium Iodide → 6-(4-Acetyl-3-hydroxy-2-propylphenoxy)hexane nitrile

HRID 543218
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HRID 543218 반응식
[CH3:1][CH2:2][CH2:3][C:4]1[C:9]([OH:10])=[C:8]([C:11]([CH3:13])=[O:12])[CH:7]=[CH:6][C:5]=1[OH:14].Cl[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(C(C)=O)C>[C:11]([C:8]1[CH:7]=[CH:6][C:5]([O:14][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22])=[C:4]([CH2:3][CH2:2][CH3:1])[C:9]=1[OH:10])(=[O:12])[CH3:13]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 2465226-ChlorohexanenitrileHCID 27751982',4'-Dihydroxy-3'-propylacetophenone

생성물 1

HCID 137633146-(4-Acetyl-3-hydroxy-2-propylphenoxy)hexane nitrile

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone
용매

실험 절차

A solution of 44.4 g. of 2,4-dihydroxy-3-propylacetophenone, 42.2 g. of 6-chlorocapronitrile, 33.2 g. of potassium carbonate and 4.0 g. of potassium iodide in one liter of methyl ethyl ketone was allowed to reflux for three days. The reaction mixture was filtered and the filtrate was evaporated in vacuo. Chromatography of the residue over silica gel (0-30% ethyl acetate gradient in hexane) gave 53.6 g. of the title product as an oil.

후처리

  1. temperatureto reflux for three days
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated in vacuo
  4. customChromatography of the residue over silica gel (0-30% ethyl acetate gradient in hexane) gave 53.6 g

출처 및 근거

ORD 기록
ord-f18112f1e0c146a59299340790a54379
출처 데이터셋
uspto-grants-1987_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04661505

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