5-Bromopentanenitrile → HCID 178439679, 화합물

HRID 543222노트

반응식

HRID 543222 반응식
[OH:1][C:2]1[C:15]([CH2:16][CH2:17][CH3:18])=[C:14]([OH:19])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].Br[CH2:21][CH2:22][CH2:23][CH2:24][C:25]#[N:26].[NH:27]1C=N[N:29]=[N:28]1>>[C:4]([C:3]1[CH:12]=[CH:13][C:14]([O:19][CH2:21][CH2:22][CH2:23][CH2:24][C:25]2[NH:26][N:29]=[N:28][N:27]=2)=[C:15]([CH2:16][CH2:17][CH3:18])[C:2]=1[OH:1])(=[O:5])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 3

HCID 794355-BromopentanenitrileHCID 13019373(2,4-Dihydroxy-3-propylphenyl)(phenyl)methanoneHCID 178418441HCID 178418441, 화합물

생성물 1

HCID 178439679HCID 178439679, 화합물

실험 절차

The title compound was prepared by first reacting 7.68 g. of 2,4-dihydroxy-3-propylbenzophenone with 4.86 g. of 5-bromovaleronitrile according to the procedure in Example 21. The reaction afforded 8.2 g. of the nitrile intermediate of the title compound. This nitrile intermediate was then converted to the tetrazole following the procedure of Example 8 giving 1.2 g. of the title compound, m.p. about 114°-115° C.

후처리

  1. customThe title compound was prepared
  2. customThe reaction afforded 8.2 g

출처 및 근거

ORD 기록
ord-02fc2c6a40c64c2a986cb49677145d01
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04661505

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