Dichloromethane → 5-tert-Butyl-2-methylbenzene-1-sulfonyl chloride

반응식

[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8](O)=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[Cl:12][S:13]([OH:16])(=O)=[O:14].[CH2:17](Cl)Cl>>[CH3:1][C:2]([C:5]1[CH:10]=[C:9]([S:13]([Cl:12])(=[O:16])=[O:14])[C:8]([CH3:17])=[CH:7][CH:6]=1)([CH3:4])[CH3:3]

참가 물질

반응물 3

HCID 6344Dichloromethane2회

HCID 73934-tert-Butylphenol

HCID 24638Chlorosulfonic acid

생성물 1

HCID 51688795-tert-Butyl-2-methylbenzene-1-sulfonyl chloride

실험 절차

12.3 g (0.075 mol) of 4-(1,1-dimethylethyl)phenol in 30 ml of methylene chloride are added dropwise, cooling in ice, to 16.5 ml of chlorosulfonic acid dissolved in 20 ml of methylene chloride. The mixture is stirred for 40 minutes and then poured onto ice-water. The organic phase is separated off, washed with water, dried with MgSO4 and evaporated. The product is recrystallized from toluene petroleum ether.