Ammonia → 5-(Tert-butyl)-2-methoxybenzenesulfonamide
반응식
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([S:13](Cl)(=[O:15])=[O:14])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[NH3:17]>CC(C)=O>[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([S:13]([NH2:17])(=[O:15])=[O:14])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1)([CH3:4])[CH3:3]참가 물질
4
실험 절차
25.3 g (0.1 mol) of 3-(1,1-dimethylethyl)-6-methoxybenzenesulfonyl chloride are dissolved in a little acetone and slowly added dropwise to 100 ml of concentrated ammonia solution at room temperature. The mixture is stirred at room temperature for 30 minutes and then poured onto ice-water. After acidification with concentrated hydrochloric acid, the product is filtered off with suction. Isopropanol is used for recrystallization. White crystals of melting point 156°-158° C.
후처리
- additionpoured onto ice-water
- filtrationAfter acidification with concentrated hydrochloric acid, the product is filtered off with suction
- customIsopropanol is used for recrystallization
출처 및 근거
- ORD 기록
- ord-19009a8660254981a33a23cf4fadc1e1
- 출처 데이터셋
- uspto-grants-1987_04
- 특허 번호
- US04661636
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