Hydrochloride methanol → 5-[3-(Amino)propylamino]imidazo[1,2-a]pyridine dihydrochloride

HRID 5434

반응식

HRID 5434 반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:18]2[CH:19]=[CH:20][N:21]=[C:17]2[CH:16]=[CH:15][CH:14]=1)=O)(C)(C)C.[ClH:22].CO>C(Cl)Cl>[ClH:22].[ClH:22].[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:18]2[CH:19]=[CH:20][N:21]=[C:17]2[CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 23362879Carbamic acid,[3-(imidazo[1,2-a]pyridin-5-ylamino)propyl]-,1,1-dimethylethyl ester

생성물 1

HCID 200866655-[3-(Amino)propylamino]imidazo[1,2-a]pyridine dihydrochloride수율 83%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of 5-[3-(tert-butoxycarbonylamino)propylamino]imidazo[1,2-a]pyridine (1.742 g, 6 mmoles) in methylene chloride (40 ml) was added hydrogen chloride-methanol (6 ml) and the mixture was stirred at room temperature for 20 hours. After the solvent was distilled off, ethanol (15 ml) and ether (30 ml) were added to the residue. Then, the crystals precipitated were filtered off and washed in turn with ether and a small amount of ethanol to obtain 1.311 g of the desired product (83.0%, pale yellow crystals).

후처리

  1. distillationAfter the solvent was distilled off
  2. additionethanol (15 ml) and ether (30 ml) were added to the residue
  3. customThen, the crystals precipitated
  4. filtrationwere filtered off
  5. washwashed in turn with ether

출처 및 근거

ORD 기록
ord-689b4b2ef67943d4b073104bea7fe4b7
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244908

연결된 노트

불러오는 중…