Dacthal → HCID 70462314, 화합물

HRID 543536

반응식

HRID 543536 반응식
CC(O[CH2:5][C:6]1[CH2:15][S:14][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:16]([OH:18])=[O:17])=O.[SH:19][C:20]1[S:24][C:23]([S:25][CH2:26][C:27]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[O:28])=[N:22][N:21]=1.COC(C1C(Cl)=C(Cl)C(C(OC)=O)=C(Cl)C=1Cl)=O>C(#N)C>[NH2:13][CH:10]1[C:11](=[O:12])[N:8]2[C:7]([C:16]([OH:18])=[O:17])=[C:6]([CH2:5][S:19][C:20]3[S:24][C:23]([S:25][CH2:26][C:27]([N:29]4[CH2:30][CH2:31][O:32][CH2:33][CH2:34]4)=[O:28])=[N:22][N:21]=3)[CH2:15][S:14][C@H:9]12

참가 물질

5

반응물 3

HCID 2943DacthalHCID 4413287-Aminocephalosporanic acidHCID 178521532HCID 178521532, 화합물

생성물 1

HCID 70462314HCID 70462314, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

While utilizing 0.680 g of 7-ACA, 0.900 g of 5-mercapto-2-morpholinocarbonylmethylthio-1,3,4-thiadiazole, 4.0 ml of acetonitrile and 2.70 g of DCPA, the procedure was carried out in accordance with Example 5, and there was obtained 1.02 g (83.3% of yield) of red brown powder of 7-amino-3-[(2-morpholinocarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid.

후처리

  1. customthere was obtained

출처 및 근거

ORD 기록
ord-291c79c7964c4fc395677d94a85f454b
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04446318

연결된 노트

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