Triethylamine → 5-(2,6-Dimethoxybenzoyl)-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoxaline

반응식

[CH2:1]1[N:5]2[C:6]3[C:11]([NH:12][CH2:13][CH:4]2[CH2:3][CH2:2]1)=[CH:10][CH:9]=[CH:8][CH:7]=3.C(N(CC)CC)C.[CH3:21][O:22][C:23]1[CH:31]=[CH:30][CH:29]=[C:28]([O:32][CH3:33])[C:24]=1[C:25](Cl)=[O:26]>CC(C)=O>[CH3:33][O:32][C:28]1[CH:29]=[CH:30][CH:31]=[C:23]([O:22][CH3:21])[C:24]=1[C:25]([N:12]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH2:1][CH2:2][CH2:3][CH:4]2[CH2:13]1)=[O:26]

참가 물질

실험 절차

To a stirred solution of the 1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoxaline 1.7 g. (0.009 mole) and 4 ml. of dry triethylamine in 50 ml. of dry acetone was added 2.5 g. (0.01 mole) of 2,6-dimethoxybenzoyl chloride. The reaction mixture was stirred for three hours and filtered, and the acetone was evaporated under vacuo. The residue was washed with water, dried and recrystallized from aqueous ethanol to afford 2.4 g. (79% yield) of the title compound, m.p. 140°-142° C.