Nitric Acid → N-[4-Chloro-2-nitro-5-(trifluoromethyl)phenyl]acetamide

HRID 54369

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HRID 54369 반응식
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([C:12]([F:15])([F:14])[F:13])[C:8]([Cl:11])=[CH:9][CH:10]=1)(=[O:3])[CH3:2].[N+:16]([O-])([OH:18])=[O:17]>OS(O)(=O)=O>[C:1]([NH:4][C:5]1[CH:6]=[C:7]([C:12]([F:15])([F:13])[F:14])[C:8]([Cl:11])=[CH:9][C:10]=1[N+:16]([O-:18])=[O:17])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 67676n-[4-Chloro-3-(trifluoromethyl)phenyl]acetamide

생성물 1

HCID 22318004N-[4-Chloro-2-nitro-5-(trifluoromethyl)phenyl]acetamide수율 91%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
0 °C

실험 절차

To 3-acetamido-6-chlorobenzotrifluoride (908 mg, 3.82 mmol) in concentrated H2SO4 (4 mL) at 0° C. was added dropwise 70% HNO3 (0.5 mL, Baker). The mixture was stirred at 0° C. for 0.5 h, then at room temperature 3 h, and it was poured into ice water (15 g). The precipitate was collected by filtration, affording 990 mg (91%) of crude 3-acetamido-6-chloro-4-nitrobenzotrifluoride. It was crystallized from EtOH/H2O to give 770 mg of pure compound as yellow needles. 1H NMR (CDCl3): δ2.326 (s, 3H), 8.345 (s, 1H), 9.293 (s, 1H), 10.222 (s, 1H).

후처리

  1. filtrationThe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-33cc602ac41342cb9e5ad6e79081599a
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622952

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