Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine | HCID 15229369 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine | HCID 15229363 | 78.1% |
반응 단계
To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (9.63 g, 49.8 mmoles) and triethylamine (7.64 ml) in methylene chloride (150 ml) was added methanesulfonyl chloride (3.85 ml, 49.7 mmoles) with stirring under ice-cooling and was stirred under ice-cooling for 1 hour. The reaction solution was poured into water and stirred. Then, the crystals precipitated were filtered off, washed with water and dried to obtain 10.53 g of the desired product (77.9%, colorless crystals).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05244908 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-0a019c1a317748ecb8ef899b9168024f |
| 출처 메모 | uspto-grants-1993_09 |