Formic Acid → HCID 15580711, 화합물

HRID 543806노트

반응식

HRID 543806 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][C:14](=[O:19])C(F)(F)F)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.C(O)=O.ClC1C=C(N2CC(C)C(NC=O)=N2)C=CC=1Cl>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][CH:14]=[O:19])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 15580693HCID 15580693, 화합물HCID 15580721HCID 15580721, 화합물

생성물 1

HCID 15580711HCID 15580711, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 2.0 g. of 3-amino-1-(m-chlorophenyl)-2-pyrazoline (prepared in Example 10) and 10 ml. of a mixture of formic acid and acetic anhydride (Example 15) is allowed to stand at room temperature for 30 minutes. Then the solvent is evaporated in vacuo to give an oil. The oil is dissolved in dichloromethane and is columnized and recrystallized as described in Example 5 to give 1.32 g. of the desired product as pale yellow needles, m.p. 143°-145° C.

후처리

  1. additionA mixture of 2.0 g
  2. customThen the solvent is evaporated in vacuo
  3. customto give an oil
  4. customrecrystallized
  5. customto give 1.32 g

출처 및 근거

ORD 기록
ord-5dd5727a5f334c8191869b11aeee9fef
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04447442

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