Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene → 2-Nitro-3,5-bis(trifluoromethyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene | HCID 19958574 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Nitro-3,5-bis(trifluoromethyl)aniline | HCID 19958571 | 71.2% |
반응 단계
A mixture of 1-acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene (200 mg, 0.63 mmol) in concentrated HCl (3 mL) and EtOH (3 mL) was refluxed overnight, then it was extracted by ethyl acetate (2×3 mL). The extract was dried over Mg2SO4 and evaporated to give 2-nitro-3,5-bis(trifluoromethyl)aniline 123 mg (71%). 1H NMR (DMSO-d6): δ6.392 (s, 2H), 7.131 (s, 1H), 7.375 (s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05622952 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-ce8d5eaebe7c42568d446175aca4b800 |
| 출처 메모 | uspto-grants-1997_04 |