Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Trifluoromethyl-1,2-phenylenediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | Benzenamine, 2-nitro-4-(trifluoromethyl)- | HCID 67865 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Trifluoromethyl-1,2-phenylenediamine | HCID 520822 | 96.9% |
반응 단계
A solution of 2-nitro-4-trifluoromethylaniline (5.000 g, 24.26 mmol, Aldrich, used as received) and SnCl2.2 H2O (20.00 g, 88.64 mmol, Aldrich, used as received) in absolute ethanol (50 mL) was refluxed for 45 min. It was then poured into ice (85 g) and basified with 10% aq. NaHCO3 (250 mL). The resulting suspension was extracted with ethyl acetate (400 mL). The ethyl acetate extract was dried over Na2SO4 and evaporated to give 4.14 g (87%) of pure 4-trifluoromethyl-1,2-phenylenediamine as a red powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05622952 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-62109381f5f14189913bf106ba37e015 |
| 출처 메모 | uspto-grants-1997_04 |