Potassium Hydroxide → HCID 12850336, 화합물

HRID 544090노트

반응식

HRID 544090 반응식
[CH3:1][C:2]1([CH3:17])[CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[C:3]1([C:15]#[N:16])[C:10]([O:12]CC)=[O:11].[OH-].[K+]>>[CH3:17][C:2]1([CH3:1])[CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[C:3]1([C:15]#[N:16])[C:10]([OH:12])=[O:11]

참가 물질

3

반응물 2

HCID 14797Potassium HydroxideHCID 12850335Ethyl 2,2-dimethyl-3-ethoxycarbonyl-1-cyano-cyclopropane-1-carboxylate

생성물 1

HCID 12850336HCID 12850336, 화합물수율 90.6%

실험 절차

A mixture of 2 g of ethyl 2,2-dimethyl-3-ethoxycarbonyl-1-cyano-cyclopropane-1-carboxylate (prepared as in U.S. Pat. No. 3,397,223) and 4.71 g of 10% ethanolic potassium hydroxide was stirred under an inert atmosphere for 15 hours and the ethanol was then evaporated under reduced pressure. The residue was washed with ether and was then taken up in ether. The pH of the solution was adjusted to 3 by addition of dilute sulfuric acid and the decanted ether phase was washed with water, dried and evaporated to dryness under reduced pressure to obtain 1.6 g of 2,2-dimethyl-3-ethoxycarbonyl-1-cyano-cyclopropane-1-carboxylic acid with a melting point of ≃130° C. (decomposition).

후처리

  1. customprepared as in U.S
  2. customthe ethanol was then evaporated under reduced pressure
  3. washThe residue was washed with ether
  4. additionThe pH of the solution was adjusted to 3 by addition of dilute sulfuric acid
  5. washthe decanted ether phase was washed with water
  6. customdried
  7. customevaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-2b48633f368f4cb4a30b8681ac8b6ae2
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04448728

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